• Thiolutin packaged and labeled in glass vial.

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SKU: T018

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Description
Thiolutin is an antibiotic first described by Tanner and co-workers in 1950. Resurgent interest in this class of microbial metabolites was stimulated by the discovery of their selective antitumor activity. Thiolutin suppresses tumor cell-induced angiogenesis in vivo.

Thiolutin is soluble in DMF and DMSO and is moderately soluble in methanol and ethanol.

    CAS Number

    87-11-6

    Molecular Formula

    C8H8N2O2S2

    Molecular Weight

    228.3

    Mechanism of Action

    Thiolutin is a potent inhibitor of bacterial and yeast RNA polymerases, and also inhibits mannan and glucan formation in fungi.

    Storage Conditions

    -20°C

Specifications

    Appearance

    Yellow orange solid

References

    References

    Studies on a common hydrolysis product of thiolutin and aureothricin. Celmer W.D. and Solomons I.A. Antibiotics Annual 1953, 622.

    Anticancer property of dithiolopyrrolones. Webster J.M. et al. 2000, US Patent 6,020,360.

    Thiolutin inhibits yeast ribonucleic acid polymerases. Tipper D.J. J. Bacteriol. 1973, 116, 245.

    Thiolutin, an inhibitor of HUVEC adhesion to vitronectin, reduces paxillin in HUVECs and suppresses tumor cell-induced angiogenesis. Minamiguchi K. Int. J. Cancer 2001, 93, 307.

    Thiolutin, an inhibitor of macromolecular synthesis in Saccharomyces cerevisiae. Mode of action. Jimenez A. Antimicrob Agents Chemother. 1973, 3, 729.

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