• Thimerosal packaged and labeled.

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SKU: T006

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Description

Thimerosal or Thiomersal is an organomercury compound with antibacterial and antifungal properties. Thimerosal was first patented by Morris Kharasch from the University of Maryland in 1927, and later given the trade name Merthiolate by Eli Lilly and Company.  Thimerosal is used as a preservative for many pharmaceutical and research applications, as well as a topical antiseptic on skin and mucous membranes.

Thimerosal is and enzyme inhibitor that is capable of inhibiting a wide range of sulfhydryl-dependent enzymes and proteins.  Thimerosal causes a release of calcium from intracellular stores in many cells types and may induce or inhibit cellular functions dependent on calcium signaling.  Thimerosal may have toxic effects to many cell types and has been shown to induce apoptosis in vitro.

Thimerosal is sparingly soluble in aqueous solution (4.6 mg/mL).

This product is considered a dangerous good. Quantities above 1 g may be subject to additional shipping fees. Please contact us for specific questions.

    CAS Number

    54-64-8

    Molecular Formula

    C9H9HgNaO2S

    Molecular Weight

    404.81

    Mechanism of Action

    Thimerosal inhibits sulfhydryl-containing active site of various enzymes and binds to sulfhydryl compounds, such as glutathione, cysteine, and SH groups of proteins. In addition, thimerosal activates the InsP3 calcium channel on endoplasmic reticular membrane, thereby triggering the release of calcium from intracellular stores resulting in a calcium-induced calcium-influx of extracellular calcium. Consequently, thimerosal may induce or inhibit cellular functions dependent on calcium signaling.

    Storage Conditions

    2-8 ┬░C

    Tariff Code

    2852.10.9000

    Spectrum

    Thimerosal is a broad-spectrum antimicrobial agent, that is effective against gram-positive bacteria gram-negative bacteria, fungi, protozoa and viruses.

Applications

    Plant Biology Applications

    Thimerosal has demonstrated antifungal properties against pathogenic fungi including Aspergillus and Fusarium species and has demonstrated greater potency than amphotericin B and natamycin.

Specifications

    Form

    Powder

    Appearance

    White or off-white powder

    Source

    Synthetic

    Loss on Drying

    Not more than 0.5%

References

    References

    The effects of thimerosal on calcium uptake and inositol 1,4,5- trisphosphate-induced calcium release in cerebellar microsomes: L.G. Sayers, et al.; Biochem. J. 289, 883 (1993)

    Disulfide linkage of biotin identifies a 106-kDa Ca2+ release channel in sarcoplasmic reticulum: N.F. Zaidi, et al.; J. Biol. Chem. 264, 21737 (1989)

    Thimerosal induces DNA breaks, caspase-3 activation, membrane damage, and cell death in cultured human neurons and fibroblasts: D. S. Baskin, et al.; Toxicol. Sci. 74, 361 (2003)

    Antibody to the inositol trisphosphate receptor blocks thimerosal- enhanced Ca(2+)-induced Ca2+ release and Ca2+ oscillations in hamster eggs: S. Miyazaki, et al.; FEBS Lett. 309, 180 (1992)

    Being on the track of thimerosal: A. Madi; Acta Microbiol. Immunol. Hung. 52, 95 (2005)

    Yan, Xu, and et al. "In Vitro Activity of Thimerosal against Ocular Pathogenic Fungi."Antimicrobial Agents and Chemotherapy 54.1 (2010): 536-39. www.ncbi.gov. Web. 28 Aug. 2012.

    Thimerosal stimulates Ca2+ flux through inositol 1,4,5-trisphosphate receptor type 1, but not type 3, via modulation of an isoform-specific Ca2+-dependent intramolecular interaction: G. Bultynck, et al.; Biochem. J. 381, 87 (2004)

    Thimerosal causes calcium oscillations and sensitizes calcium-induced calcium release in unfertilized hamster eggs: K. Swann; FEBS Lett. 278, 175 (1991), 

    Thimerosal: a versatile sulfhydryl reagent, calcium mobilizer, and cell function-modulating agent:: J.G. Elferink; Gen. Pharmacol. 33, 1 (1999), (Review),

     




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