• Terrein packaged and labeled in glass vial.

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SKU: T083

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Description
Terrein is a polar, substituted dihydrocyclopentenone first reported by Raistrick and colleagues in the 1930s and subsequently found in a number of Aspergillus and Penicillium species.

Terrein is soluble in ethanol, methanol, DMF and DMSO.

    CAS Number

    582-46-7

    Molecular Formula

    C8H10O3

    Molecular Weight

    154.2

    Mechanism of Action

    Recent research shows that terrein reduces melanin synthesis by reducing tyrosinase production via ERK activation, followed by MITF down-regulation. Terrein also reduces human keratinocyte proliferation by inhibiting ERK and by decreasing the expression of cyclin B1 and Cdc2 complex.

    Storage Conditions

    -20°C

Specifications

    Appearance

    Light tan solid

References

    References

    Studies in the biochemistry of micro-organisms: The metabolic products of Aspergillus terreus Thom. A new mould metabolic product, terrein. Raistrick H. & Smith G. Biochem. J. 1935, 29, 606.

    Terrein: a new melanogenesis inhibitor and its mechanism. Park S.H. et al. Cell. Mol. Life Sci. 2004, 61, 2878.

    Terrein inhibits keratinocyte proliferation via ERK inactivation and G2/M cell cycle arrest. Kim D.S. et al. Exp. Dermatol. 2008, 17, 312.

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