• Terrecyclic Acid packaged and labeled in glass vial.

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SKU: T082

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Description
Terrecyclic acid is a tricyclic sesquiterpene antibiotic produced by Aspergillus terreus, first reported by researchers at the Universities of Osaka and Tokyo in 1982. Terrecyclic acid A had a wide antimicrobial spectrum of rather weak activities against gram-positive bacteria, yeasts and fungi, and shows antitumor activity against lymphocytic leukemia P388.

Terrecyclic acid induces the heat shock protein response and affects oxidative and inflammatory cellular stress response pathways in tumor cells that promote survival.  Terrecyclic Acid A is shown to increase reactive oxygen species (ROS) in 3LL cells, as well as, inhibit cytokine-induced NF-kappaB transcriptional activity.

Terrecyclic acid is soluble in ethanol, methanol, DMF and DMSO.

    CAS Number

    83058-94-0

    Molecular Formula

    C15H20O3

    Molecular Weight

    248.3

    Mechanism of Action

    No studies of the mode of action of terrecyclic acid have been published.

    Storage Conditions

    -20°C

    Spectrum

    Terrecyclic acid A had a wide antimicrobial spectrum of rather weak activities against gram-positive bacteria, yeasts and fungi, and shows antitumor activity against lymphocytic leukemia P388. 

Applications

    Cancer Applications

    Terrecyclic acid induces the heat shock protein response and affects oxidative and inflammatory cellular stress response pathways in tumor cells that promote survival. Terrecyclic Acid A is shown to increase reactive oxygen species (ROS) in 3LL cells, as well as, inhibit cytokine-induced NF-kappaB transcriptional activity.

Specifications

    Appearance

    Light tan residue

References

    References

    Terrecyclic acid A, a new antibiotic from Aspergillus terreus. I. Taxonomy, production and chemical and biological properties. Nakagawa M. et al. J. Antibiot. 1982, 35, 778.

    The anticancer activity of the fungal metabolite terrecyclic acid A is associated with modulation of multiple cellular stress response pathways. Turbyville T.J. et al. Mol. Cancer Ther. 2005, 4, 1569.

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