• Temsirolimus packaged and labeled in glass vial.

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SKU: T077

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Description
Temsirolimus is a semisynthetic macrocyclic lactone prepared from rapamycin by selective acylation of the 42-hydroxy group with a protected bis(dihydromethyl)propionic acid, followed by deprotection. Temsirolimus is extensively cited in the literature with over 700 citations.

Temsirolimus is soluble in ethanol, methanol, DMF and DMSO.

    CAS Number

    162635-04-3

    Molecular Formula

    C56H87NO16

    Molecular Weight

    1030.3

    Mechanism of Action

    Temsirolimus binds to receptor protein, FKBP12. The complex then binds to mTOR preventing it from interacting with target proteins.

    Storage Conditions

    -20°C

Specifications

    Appearance

    White solid

References

    References

    Rapamycin hydroxyesters. Skotnicki J. US Patent 5,362,718, 1994.

    CCI-779 inhibits rhabdomyosarcoma xenograft growth by an antiangiogenic mechanism linked to the targeting of mTOR/Hif-1α/VEGF signaling. Wan X. et al. Neoplasia 2006, 8, 394.

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