• Teleocidin A1 packaged and labeled in glass vial.

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SKU: T075

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Description
Teleocidin A is a potent nematocide and acaricide produced by Streptoverticillium strains, first reported in 1960. Teleocidin A is a potent activator of protein kinase C, and also a tumor promoting agent and inducer of colony-stimulating factors. More recently, teleocidin A1 has been shown to regulate the expression of several genes. To date, the lack of availability of teleocidin has meant the truncated teleocidin-like (-)indolactam has been used to mimic teleocidin cellular responses.

Teleocidin A is soluble in ethanol, methanol, DMF and DMSO.

    CAS Number

    70497-14-2

    Molecular Formula

    C27H39N3O2

    Molecular Weight

    437.7

    Storage Conditions

    -20°C

Specifications

    Appearance

    White to light tan solid

References

    References

    A new toxic substance, teleocidin, produced by Streptomyces. Part I. Production, isolation and chemical studies. Takashima M. & Sakai H. Bull. Agr. Chem. Soc. Japan 1960, 24, 647.

    Screening method for colony-stimulating factor inducers using a human bone marrow stromal cell line, KM-102. Kohama T. et al. J. Antibiot. 1993, 46, 1494.

    Activity of mangosteen xanthones and teleocidin a-2 in death receptor expression enhancement and tumor necrosis factor related apoptosis-inducing ligand assays. Kikuchi H. J. Nat. Prod. 2010, 73, 452.

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