• Streptonigrin packaged and labeled in glass vial.

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SKU: S071

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Description
Streptonigrin is an unusual aminoquinone with broad biological activity against bacteria, fungi, nematodes, viruses and tumor cells. Streptonigrin acts as a bioreductive agent, highly dependent on interactions with metal ions, notably iron, and plays an important role in free radical production through redox cycling of NAD(P)H:quinone oxidoreductase (NQO1).

Streptonigrin is soluble in DMF and DMSO and is moderately soluble in methanol or ethanol.

    CAS Number

    3930-19-6

    Molecular Formula

    C25H22N4O8

    Molecular Weight

    506.5

    Storage Conditions

    -20°C

Specifications

    Appearance

    Brown black solid

References

    References

    Targeting NAD(P)H:quinone oxidoreductase (NQO1) in pancreatic cancer. Lewis A.M. Mol. Carcinogen. 2005, 43, 215.

    Enhanced cytotoxicity of bioreductive antitumor agents with dimethyl fumarate in human glioblastoma cells. Gu B. & DeAngelis L.M. Anticancer Drugs 2005, 16, 167.

    The effect of metal ions on the electrochemistry of the antitumor antibiotic streptonigrin. Anderberg P.I. J. Inorg. Biochem. 2004, 98, 720.

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