• Steffimycin B packaged and labeled in glass vial.

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SKU: S102

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Description
Steffimycin B is an anthracycline metabolite isolated from a Streptomyces sp. with antibacterial and antineoplastic properties. Crystallographic studies of binding to DNA suggest that it has a higher CpG base sequence specificity over the TpA step, similar to that of daunorubicin and nogalamycin. A close analogue was shown to be active against ras oncogene-expressed cells.

Steffimycin B is soluble in ethanol, methanol, DMF and DMSO.

    CAS Number

    54526-94-2

    Molecular Formula

    C29H32O13

    Molecular Weight

    588.6

    Storage Conditions

    -20°C

Specifications

    Appearance

    Orange Lyophilisate

References

    References

    Molecular structure of antitumor drug steffimycin and modeling of its binding to DNA. Sriram M. et al. J. Biomol. Struct. Dyn. 1991, 9, 251.

    Screening of antibiotics preferentially active against ras oncogene-expressed cells. Suzukake-Tsuchiya K. et al. J. Antibiot. 1990, 43, 1489.

    Steffimycin B, a DNA binding agent. Reusser F. Biochim. Biophys. Acta 1975, 383, 266.

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