• Staurosporine packaged and labeled in glass vial.

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SKU: S070

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Description
Staurosporine is an unusual indolocarbazole alkaloid produced by a range of actinomycete species. It is a potent antitumor active, inducing apoptosis in a variety of cell lines. At submicromolar concentrations, staurosporine inhibits both IKKalpha and IKKbeta.

Staurosporine is soluble in ethanol, methanol, DMF and DMSO.

    CAS Number

    62996-74-1

    Molecular Formula

    C28H26N4O3

    Molecular Weight

    466.5

    Mechanism of Action

    Staurosporine is a potent inhibitor of many kinases including protein kinase C, tyrosine kinase, CDK2/cyclin A and CDK4/cyclin D.

    Storage Conditions

    -20°C

Specifications

    Appearance

    White solid

References

    References

    IkappaB kinases alpha and beta show a random sequential kinetic mechanism and are inhibited by staurosporine and quercetin. Peet G.W. et al. J. Biol. Chem. 1999, 274, 32655.

    Characterization of the cell death process induced by staurosporine in human neuroblastoma cell lines. Boix J. et al. Neuropharmacology 1997, 36, 811.

    Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases. Ruegg U.T. et al. Trends Pharmacol. Sci. 1989, 10, 218.

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