• Siccanin packaged and labeled in glass vial.

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SKU: S082

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Description
Siccanin is an unusual fused phenolic pentacycle first isolated from Helminthosporium siccans and reported in 1962 as a potent antifungal agent. Siccanin inhibits succinate dehydrogenase in the terminal electron transport system. More recent studies note the proximity of the siccanin binding site to the quinone-binding site of the enzyme. Species-selective inhibition by siccanin is unique among succinate dehydrogenase inhibitors and offers a lead for new chemotherapeutics.

Siccanin is soluble in ethanol, methanol, DMF and DMSO.

    CAS Number

    22733-60-4

    Molecular Formula

    C22H30O3

    Molecular Weight

    342.5

    Mechanism of Action

    Siccanin inhibits succinate dehydrogenase in the terminal electron transport system.

    Storage Conditions

    -20┬░C

Specifications

    Appearance

    White solid

References

    References

    Studies on antibiotics from Helminthosporium sp. fungi. VII Siccanin, a new antifungal antibiotic produced by Helminthopsporium siccans. Ishibashi K. J. Antibiot. Series A 1962, 15, 161.

    Mode of action of the antibiotic siccanin on intact cells and mitochondria of Trichophyton mentagrophytes. Nose K. & Endo A. J. Bacteriol. 1971, 105, 176.

    Siccanin rediscovered as a species-selective succinate dehydrogenase inhibitor. Mogi T.J. et al. Biochem. 2009, 146, 383.

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