• Sancycline hydrochloride packaged and labeled in glass vial.

click on thumbnail to zoom
SKU: S076

Size  
Quantity:
  Click 'Bulk Order' for 10 or more
Price: make selection(s)
Description
Sancycline hydrochloride is the hydrochloride salt of a rare semi-synthetic tetracycline prepared by hydrogenolysis of the chloro and benzylic hydroxy moieties of declomycin, first reported in 1962. As the simplest of the early tetracyclines, sancycline was the first to be totally synthesised by Conover and co-workers.

Sancycline hydrochloride is soluble in ethanol, methanol, DMF and DMSO. 

    CAS Number

    6625-20-3

    Molecular Formula

    C21H23ClN2O7

    Molecular Weight

    450.9

    Mechanism of Action

    Sancycline acts by reversibly binding to the 30S ribosomal subunit and inhibiting protein translation by blocking entry of aminoacyl-tRNA into the ribosome A site.

    Storage Conditions

    -20°C

Specifications

    Appearance

    Yellow to orange solid

References

    References

    Process for the catalytic reduction of 6-hydroxynaphthacenes. McCormick J.R.D. & Jensen E.R. 1962 US Patent 3,019,260.

    The total synthesis of 6-demethyl-6-deoxytetracycline. Conover L.H. et al. J. Am. Chem. Soc. 1962, 84, 3222.

Other Items In This Category