Salinomycin sodium

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Salinomycin sodium

SKU: S002

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Description

Salinomycin is a coccidiostat ionophore antibiotic.

TOKU-E offers two forms of salinomycin: salinomycin (S001) and salinomycin sodium (S002). Salinomycin is slightly soluble in methanol at 10 mg/mL. Salinomycin sodium is insoluble in water, freely soluble in acetone, and 200 mg/mL soluble in ethanol.

This product is considered a dangerous good. Quantities above 1 g may be subject to additional shipping fees. Please contact us for specific questions.

Fangyuan Xie et al. used salinomycin from TOKU-E to study its efficacy toward liver cancer cells when used in combination with chloroquine. Read more here: "Codelivery of salinomycin and chloroquine by liposomes enables synergistic antitumor activity in vitro."

CAS Number

55721-31-8

Molecular Formula

C₄₂H₆₉NaO₁₁

Molecular Weight

772.98 (anhydrous basis)

Mechanism of Action

Salinomycin interacts with the gram positive cell membrane which decreases control of ion permeability. This effect allows ions (K⁺, Na⁺, Ca⁺, Mg²⁺) to accumulate inside the cell to toxic levels.

Storage Conditions

2-8°C

Tariff Code

2941.90.1050

Spectrum

Salinomycin targets primarily the gram positive cell wall to allow ion transport into the cell. Gram negative organisms are unaffected by salinomycin because of their additional outer membrane.

Applications

Microbiology Applications

Salinomycin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

Clostridium perfringins 0.12 µg/mL – 0.25 µg/mL
For a complete list of salinomycin MIC values, click here.

Specifications

Form

Powder

Appearance

White crystalline powder

Source

Streptomyces albus

Impurity Profile

Arsenic: ≤0.0004%
Elaiophilin: ≤0.0032%

pH

6.5-8.5

Melting Point

140-142°C

Assay

(Dried Basis): ≥900u/mg

Loss on Drying

≤7.0%

Heavy Metals

Not more than 0.002%

Technical Data

References

Adam Huczynski (2012). "Salinomycin – a New Cancer Drug Candidate". Chemical Biology & Drug Design 79: 235–238.

Yurkovich, Marie E. et al.; Tyrakis, Petros A.; Hong, Hui; Sun, Yuhui; Samborskyy, Markiyan; Kamiya, Kohei; Leadlay, Peter F. (2011-11-11). "A Late-Stage Intermediate in Salinomycin Biosynthesis Is Revealed by Specific Mutation in the Biosynthetic Gene Cluster". ChemBioChem 13 (1): 66–71.

Gupta, P. et al.; Onder, Tamer T.; Jiang, Guozhi; Tao, Kai; Kuperwasser, Charlotte; Weinberg, Robert A.; Lander, Eric S. (2009-08-13). "Identification of selective inhibitors of cancer stem cells by high-throughput screening". Cell 138 (4): 645–59