• Roseoflavin packaged and labeled in glass vial.

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SKU: R039

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Description
Roseoflavin is an antibacterial pigment isolated from Streptomyces davawensis as an anti-metabolite of riboflavin. Roseoflavin has been shown to be an important regulator of bacterial gene expression by binding to untranslated regions of RNA, so-called ribo-switching sites.

Roseoflavin is soluble in ethanol, methanol, DMF and DMSO.

    CAS Number

    51093-55-1

    Molecular Formula

    C18H23N5O6

    Molecular Weight

    405.4

    Mechanism of Action

    Roseoflavin is used as a substrate to mimic riboflavin in flavin biosynthesis, but leading to the formation of inactive flavin co-factors.

    Storage Conditions

    -20°C

Specifications

    Appearance

    Red solid

References

    References

    Roseoflavin, a new antimicrobial pigment from Streptomyces. Otani S. et al. J. Antibiot. 1994, 27, 86.

    The bifunctional flavokinase/flavin adenine dinucleotide synthetase from Streptomyces davawensis produces inactive flavin cofactors and is not involved in resistance to the antibiotic roseoflavin. Grill S. et al. J. Bacteriol. 2008, 190, 1546.

    Riboswitches as antibacterial drug targets Blount K.F. & Breaker R.R.: Nat. Biotechnol. 2006, 24, 1558.

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