• Rolitetracycline packaged and labeled in glass vial.

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SKU: R023

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Description
Rolitetracycline, launched in the late 1950s, was the first of the semi-synthetic tetracyclines. Rolitetracycline is formed by a Mannich condensation of formaldehyde and pyrrolidine with tetracycline. Rolitetracycline is a pro-drug of tetracycline, in which the pyrrolidine moiety improves bioavailability compared with tetracycline. Rolitetracycline has broad spectrum Gram positive activity in vivo, but pH instability limits use to parenteral administration. The intrinsic in vitro activity and SARs for this region of the tetracycline molecule have not been extensively investigated.

Rolitetracycline is soluble in in water and partially soluble in ethanol and methanol.  

    CAS Number

    751-97-3

    Molecular Formula

    C27H33N3O8

    Molecular Weight

    527.6

    Storage Conditions

    -20°C

Specifications

    Appearance

    Yellow to orange solid

References

    References

    Mannich bases of tetracycline antibiotics. Cheney L.C. et al. 1963 US Patent 3,104,240.

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