SKU: R028

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Description
Reticulol is an isocoumarin metabolite produced by selected species of Streptomyces. Reticulol was first described as a potent inhibitor of cyclic nucleotide phosphodiesterase but more recent research has demonstrated a topoisomerase I inactivation mechanism. Reticulol also causes dose dependent inhibition of lung metastasis in the B16F10 melanoma model.

Reticulol is soluble in ethanol, methanol, DMF and DMSO. 

    CAS Number

    224452-66-8

    Molecular Formula

    C30H47NO4S

    Molecular Weight

    517.8

    Storage Conditions

    -20°C

Specifications

    Appearance

    White solid

References

    References

    Activity of retapamulin (SB-275833), a novel pleuromutilin, against selected resistant gram-positive cocci. Jones R. et al. Antimicrob. Agents Chemother. 2006, 50, 2583.

    Retapamulin. Daum R.S. et al. Nature Reviews Drug Discovery 2007, 6, 865.

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