• Rebeccamycin packaged and labeled in glass vial.

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SKU: R021

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Description
Rebeccamycin is an indolocarbazole isolated from Lechevalieria aerocolonigenes. Rebeccamycin displays selective antitumor activity against several cell lines. Analogues of rebeccamycin have been tested in clinical trials for cancer therapy.

Rebeccamycin is soluble in DMF and DMSO and is moderately soluble in methanol or ethanol. 

    CAS Number

    93908-02-2

    Molecular Formula

    C27H21Cl2N3O7

    Molecular Weight

    570.4

    Mechanism of Action

    Rebeccamycin's primary mechanism of action is via strong DNA intercalation resulting in the potent catalytic inhibition of both topoisomerases I and II.

    Storage Conditions

    -20°C

Specifications

    Appearance

    Dull yellow lyophilisate

References

    References

    Discovery of antitumor indolocarbazoles: rebeccamycin, NSC 655649, and fluoroindolocarbazoles. Long B. H., et al. , Curr. Med. Chem. Anticancer Agents, 2002, 2, 255.

    Active site mutations in DNA topoisomerase I distinguish the cytotoxic activities of camptothecin and the indolocarbazole, rebeccamycin. Woo M. H., et al. , J. Biol. Chem., 2002, 277, 3813.

    Production and biological activity of rebeccamycin, a novel antitumor agent. Bush J. A., et al. , J. Antibiot., 1987, 40, 668.

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