• Ramoplanin packaged and labeled in glass vial.

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SKU: R024

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Description
Ramoplanin is a complex of three high molecular weight glycolipodepsipeptides, varying in the chain length and shape of the dieneone lipid side-chain. Ramoplanin was isolated in the early 1980s as the major metabolite of a strain of Actinoplanes with antiviral and antibiotic activity against drug resistant Gram positive isolates.

Ramoplanin is soluble in ethanol, methanol, DMF and DMSO.

    CAS Number

    76168-82-6

    Molecular Formula

    C119H154ClN21O40 (for A2)

    Molecular Weight

    2554.1 (for A2)

    Mechanism of Action

    Ramoplanin acts by inhibiting cell wall biosynthesis via a different mechanism from the vancomycin-related glycopeptides.

    Storage Conditions

    -20°C

Specifications

    Appearance

    White solid

References

    References

    A-16686, a new antibiotic from Actinoplanes. I. Fermentation, isolation and preliminary physico-chemical characteristics. Cavalleri B. et al. J. Antibiot. 1984, 37, 309.

    Bactericidal activity of ramoplanin against antibiotic-resistant enterococci. Johnson C.C. et al. Antimicrob. Agents Chemother. 1992, 36, 2342.

    Ramoplanin: a lipoglycodepsipeptide antibiotic. Farver D.K. et al. Ann. Pharmacother. 2005, 39, 863.

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