• RK-682 packaged and labeled in glass vial.

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SKU: R033

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Description
RK-682 is a dimeric calcium complex of the major analogue of a tetronic acid complex isolated from Streptomyces. Although reported by researchers at RIKEN in 1995, subsequent synthesis in 2001 showed that RK-682 was in fact the calcium complex formed during silica chromatography. Confusion about the structure of RK-682 has lead to the monomeric sub-unit, TAN 1364B (3-hexadecanoyl-5-hydroxymethyltetronic acid) being mis-named as RK-682 by many suppliers. 

RK-682 is soluble in ethanol, methanol, DMF and DMSO.

    CAS Number

    332131-32-5

    Molecular Formula

    C42H70CaO10

    Molecular Weight

    775.1

    Mechanism of Action

    RK-682 inhibits protein tyrosine phosphatases, phospoholipase A2, heparinase and HIV-1 protease. It is unclear whether biological activity is due to the monomer (TAN 1364B) or dimeric complex (RK-682).

    Storage Conditions

    -20°C

Specifications

    Appearance

    White Solid

References

    References

    RK-682, a potent inhibitor of tyrosine phosphatase, arrested the mammalian cell cycle progression at G1phase. Hamaguchi T. et al. FEBS Lett. 1995, 372, 54. 

    Structure-based design of a selective heparanase inhibitor as an antimetastatic agent. Ishida K. et al. Mol. Cancer Ther. 2004, 3, 1069. 

    The mechanism of ATP-induced long-term potentiation involves extracellular phosphorylation of membrane proteins in guinea-pig hippocampal CA1 neurons. Fujii S. et al. Neurosci. Lett. 1995, 187, 130. 

    Asymmetric synthesis of a 3-acyltetronic acid derivative, RK-682, and formation of its calcium salt during silica gel column chromatography. Sodeoka M. et al. Chem. Pharm. Bull. 2001, 49, 206

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