• Quinupristin-Dalfopristin mesylate packaged and labeled in glass vial.

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SKU: Q009

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Description
Quinupristin-dalfopristin mesylate is a 70:30 (w/w) complex of two semi-synthetic analogues marketed as Synercid. Dalfopristin is a semisynthetic analogue of virginiamycin M, while quinupristin is a semi-synthetic analogue of virginiamycin B. To optimise stability, the compounds are presented as the mesylate salts with 10% sodium mesylate excess to provide a buffered aqueous solution. The complex is more hydrophobic than the naturally-occurring virginiamycin complex, with a readily ionisable group for generating a salt for improved solubility. There is little published data on the synthesis and biological activity of individual components of the complex, however the combination is a highly effective antibiotic, including activity against resistant strains.

Quinupristin-dalfopristin mesylate is soluble in ethanol, methanol, DMF and DMSO. 

    CAS Number

    126602-89-9

    Molecular Formula

    C54H71N9O13S2 (for quinupristin mesylate); C35H54N4O12S2 (for dalfopristin mesylate)

    Molecular Weight

    1118.3 (for quinupristin mesylate) ; 786.9 (for dalfopristin mesylate)

    Storage Conditions

    -20┬░C

Specifications

    Appearance

    White to light yellow solid

References

    References

    Quinupristin/dalfopristin (RP 59500): A new streptogramin antibiotic. Chant C. et al. Ann. Pharm. 1995, 29, 1022.

    Quinupristin/dalfopristin: spectrum of activity, pharmacokinetics, and initial chemical experience. Low D. Microb. Drug Resist. 1995, 1, 223.

    Quinupristin/dalfopristin: a therapeutic review. Allington D.R. & Rivey M.P. Clin. Ther. 2001, 23, 24.

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