• Questiomycin A packaged and labeled in glass vial.

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SKU: Q004

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Description
Questiomycin A is a phenoxazine produced by several Streptomyces species and some fungi and bacteria. Questiomycin A is weakly active against bacteria, fungi, plants and tumor cell lines, and inhibits aromatase and sulfatases. More recently, questiomycin A has been shown to inhibit pulmonary metastasis caused by mouse melanoma cells. Questiomycin A and related phenoxazines are important dereplication standards in discovery research to eliminate leads due to high amounts of weakly potent actives.

Questiomycin A is soluble in ethanol, methanol, DMF and DMSO.

    CAS Number

    1916-59-2

    Molecular Formula

    C12H8N2O2

    Molecular Weight

    212.2

    Mechanism of Action

    Questiomycin stimulates cell growth and turnover in vitro, an activity possibly related to their ability to form stable free radicals.

    Storage Conditions

    -20┬░C

Specifications

    Appearance

    Red to red brown solid

References

    References

    The new antibiotics, questiomycins A and B. Anzai K. et al. J. Antibiot. 1960, 13, 125.

    Studies on cell growth stimulating substances of low molecular weight. Imai S. et al. J. Antibiot. 1993, 46, 1232.

    2-Aminophenoxazine-3-one prevents pulmonary metastasis of mouse B16 melanoma cells in mice. Hongo T. J. Pharmacol. Sci. 2010, 114, 63.

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