• Pyridomycin packaged and labeled in glass vial.

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SKU: P100

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Description
Pyridomycin is a potent antibiotic active against mycobacteria and some Gram negative bacteria, originally isolated from Streptomyces abidoflavus by Umezawa group at the NIH Japan in 1953, and since isolated from different species and published under several names. The unusual 12-membered macrocyclic depsipeptide comprises three unique sub-units incorporating two substituted pyridines. Recent reports of activity against isoniazid-resistant mycobacteria has seen pyridomycin identified as a potential lead for new generation antibiotics.

Pyridomycin is soluble in ethanol, methanol, DMF and DMSO.

    CAS Number

    18791-21-4

    Molecular Formula

    C27H32N4O8

    Molecular Weight

    186.2

    Mechanism of Action

    Pyridomycin is thought to target NADH-dependent enoyl (acyl-carrier-protein) reductase InhA.

    Storage Conditions

    -20┬░C

Specifications

    Appearance

    White solid

References

    References

    A new antibiotic, pyridomycin. Maeda K. et al. J. Antibiot. 1953, 6, 140.

    Towards a new tuberculosis drug: pyridomycin – nature’s isoniazid. EMBO Mol. Med. 2012, 4, 1032.

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