• Oxytetracycline hydrochloride packaged and labeled.

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SKU: O004

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Description

Oxytetracycline was the second discovered tetracycline antibiotic.

TOKU-E offers two forms of oxytetracycline: Oxytetracycline Dihydrate (O003)and Oxytetracycline Hydrochloride (O004). Oxytetracycline dihydrate is sparingly soluble in aqueous solution at 0.6 mg/mL. Oxytetracycline HCl is slightly soluble in aqueous solution at 6.9 mg/mL.

    CAS Number

    2058-46-0

    Molecular Formula

    C22H24N2O9•HCl

    Molecular Weight

    496.89

    Mechanism of Action

    The mechanism of oxytetracycline involves diffusing through a cell and binding to the 30s ribosomal subunit preventing peptide elongation and ultimately inhibiting protein synthesis. Resistance to oxytetracycline can be a result of inactivation by cell enzymes or pumping the antibiotic out of the cell upon entering.

    Storage Conditions

    2-8°C

    Tariff Code

    2941.30.0000

    Spectrum

    Oxytetracycline is a broad spectrum antibiotic which targets gram positive and gram negative species as well as a few Mycoplasma species

Applications

    Microbiology Applications

    Oxytetracycline is commonly used in clinical in vitromicrobiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive, gram negative, and Mycoplasma microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Haemophilus influenzae 1.6 µg/mL – 6.3 µg/mL
    • Mycoplasma bovis 0.12 µg/mL - 4 µg/mL
    • For a complete list of oxytetracycline MIC values, click here.

    Media Supplement

    Oxytetracycline is used as a selective agent in OGYE, a selective media for yeasts and molds.

    Plant Biology Applications

    Oxytetracycline has been used to prevent fire blight in apple and pears in the Pacific Northwest of the USA. In a study by Hubbard et al., oxytetracycline was shown to be a better alternative to streptomycin to inhibit fire blight disease.

Specifications

    Form

    Powder

    Appearance

    Yellow crystalline powder

    Water Content (Karl Fisher)

    6.0-9.0%

    pH

    2.0-3.0

    Melting Point

    180 °C

    Assay

    (On Dried Basis): ≥835µg/mg

    Loss on Drying

    ≤2.0%

References

    References

    Chopra, Ian, and Marilyn Roberts. "Tetracycline Antibiotics: Mode of Action, Applications, Molecular Biology, and Epidemiology of Bacterial Resistance." Microbiology and Molecular Biology Reviews (2001): 232-60. Http://www.ncbi.nlm.nih.gov. Web. 21 Aug. 2012.

    Hubbard A.R., 2011, Evaluation of Kasugamycin-use strategies Designed to Delay Development of Resistance in Erwinia amylovora. Master thesis of Botany and Plant Pathology, Oregon state University.

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