• Nitrofurantoin packaged and labeled.

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SKU: N006

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Description

Nitrofurantoin is a unique bacteriostatic antibiotic. Nitrofurantoin is sparingly soluble in aqueous solution at 0.0795 mg/mL; however, it is highly soluble in DMF at 80 mg/mL.

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    CAS Number

    67-20-9

    Molecular Formula

    C8H6N4O5

    Molecular Weight

    238.16

    Mechanism of Action

    Upon entering a susceptible cell, nitrofurantoin is activated by bacterial enzymes and targets ribosomes and nucleic acids which inhibit bacterial growth.

    Storage Conditions

    Store protected from light at ambient temperature.

    Tariff Code

    2934.99.4700

    Spectrum

    Nitrofurantoin is a broad spectrum antibiotic frequently used to treat bacterial infections of the urinary tract. Nitrofurantoin has been found to be effective against certain β-lactam resistant strains of VRE or vancomycin resistant Enterococcus; a glycopeptide antibiotic resistant "superbug."

Applications

    Microbiology Applications

    Nitrofurantoin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Escherichia coli 32 µg/mL - 64 µg/mL
    • For a complete list of nitrofurantoin MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    Yellow crystalline powder

    Source

    Synthetic

    Impurity Profile

    Limit of Nitrofurfural Diacetate: ≤ 1.0%
    Limit of Nitrofurazone: ≤ 0.01%

    Water Content (Karl Fischer)

    < 1.0%

    Assay

    (On dried basis): 98.0-102.0%

References

    References

    Fitzpatrick, Penny M., and Charles C. McOsker. "Nitrofurantoin: Mechanism of Action and Implications for Resistance Development in Common Uropathogens." Journal of Antimicrobial Chemotherapy (1994): Oxfordjournals.org. Web. 21 Aug. 2012.

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