SKU: F041

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Description
Flomoxef Sodium is a beta-lactam inhibitor with a broad spectrum of activity. Its antibiotic properties have been used to treat respiratory infections, osteoporosis, and other bone diseases.

    CAS Number

    92823-03-5

    Molecular Formula

    C15H18F2N6NaO7S2

    Molecular Weight

    519.451

    Mechanism of Action

    Flomoxef Sodium is a beta-lactam inhibitor that acts by inhibiting cell-wall synthesis. This is performed by binding to penicillin-binding proteins which prevents the transpeptidation step of peptidoglycan synthesis in bacterial cell walls, leading to the inhibition of cell-wall biosynthesis.

    Spectrum

    Flomoxef Sodium has a broad spectrum of activity. It is a fourth-generation cephalosporin that has great gram-negative activity and is active against an array of gram-positive organisms including MRSA.

References

    References

    Ito M & Ishigami T: The meaning of the development of flomoxef and clinical experience in Japan (abstract). Infection 1991; 19 (suppl 5):S253-S257.

    Ruckdeschel G & Eder W: Comparative in vitro activity of the new oxacephem antibiotic, flomoxef. Eur J Clin Microbiol Infect Dis 1988; 7:687-691.

    Gilman AG, Rall TW, Nies AS, et alGilman AG, Rall TW, Nies AS, et al (Eds): Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th. Macmillan Publishing Co, New York, NY, 1990.

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