• Doxorubicin hydrochloride, USP packaged and labeled.

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SKU: D005

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Description

Doxorubicin HCl is an anthracycline antibiotic and 12-hydroxylated version of daunorubicin that inhibits macromolecular biosynthesis through DNA intercalation.

    CAS Number

    25316-40-9

    Molecular Formula

    C27H29NO11•HCl

    Molecular Weight

    579.98

    Mechanism of Action

    Doxorubicin stops the development of the topoisomerase II enzyme, which relaxes supercoils in DNA for transcription. Doxorubicin stabilizes the topoisomerase II complex after it has broken the DNA chain for replication, which prevents the DNA double helix from being resealed and thereby inhibits the replication process.

    Storage Conditions

    2-8 °C

    Tariff Code

    2941.90.3000

Applications

    Cancer Applications

    Doxorubicin is given to treat non-Hodgkin's lymphoma, multiple myeloma, acute leukemias, Kaposi sarcoma, Ewing sarcoma, Wilm tumor, and cancers of the breast, adrenal cortex, endometrium, lung, ovary, and other sites. It is sometimes used to treat non-cancerous conditions as well.

Specifications

    Form

    Powder

    Appearance

    Orange-red crystalline powder

    Source

    Streptomyces Peucetius

    Impurity Profile

    Impurity A| (8S,10S)-8-acetyl-10-[(3-amino-2,3,6-trideoxy-l-lyxo-hexopyranosyl)oxy]-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione (daunorubicin)|||| Impurity B| (8S,10S)-10[(3-amino-2,3,6-trideoxy-l-lyxo-hexopyranosyl)oxy]-8-(2-bromo-1,1-dimethoxyethyl)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione|||| Impurity C| (8S,10S)-10[(3-amino-2,3,6-trideoxy-l-lyxo-hexopyranosyl)oxy]-8-(bromoacetyl)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione|||| Impurity D| (8S,10S)-6,8,10,11-tetrahydroxy-8-(hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione (doxorubicin aglycone, doxorubicinone)|

    Water Content (Karl Fisher)

    ≤4.0%

    pH

    4.0-5.5

    Melting Point

    204-205°C

    Assay

    (On Dried Basis): 98.0-102.0%

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