• Pleuromutilin packaged and labeled in glass vial.

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SKU: P091

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Description
Pleuromutilin is a diterpene produced by several species of basidomycete, notably the genus Pleurotus, discovered in 1951. Pleuromutilin is a potent and highly selective antibiotic active against a range of Gram positive bacteria, with no cross resistance to existing antibiotic classes due to its unique mode of action.

Pleuromutilin is soluble in ethanol, methanol, DMF and DMSO.

    CAS Number

    125-65-5

    Molecular Formula

    C22H34O5

    Molecular Weight

    378.5

    Mechanism of Action

    Pleuromutilin inhibits protein synthesis by binding to domain V of 23S rRNA and this has led to the development of many semi-synthetic analogues as new generation antibiotics, such as tiamulin and retapamulin.

    Storage Conditions

    -20┬░C

Specifications

    Appearance

    White solid

References

    References

    Antibiotic substances from basidomycetes. VIII. Pleurotus mutilus (Fr.) Sacc. & Pleurotus passeckerianus Pilat. Kavanagh F. et al. , Proc. Natl. Acad. Sci. USA 1951, 37, 570.

    Pleuromutilin antibiotics. Hunt E., Drugs Future 2000, 25, 1163.

    Pleuromutilins. Part 1. The indentification of novel mutilin 14-carbamates. Brooks G. et al. , Bioorg. Med. Chem. 2001, 9, 1221.

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