• Platencin packaged and labeled in glass vial.

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SKU: P089

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Description
Platencin is a novel, broad spectrum, Gram-positive antibiotic produced by strains of Streptomyces platensis. Platencin is more potent than its analogue, platensimycin. Platencin shows potent in vivo efficacy without any observed toxicity. Platencin targets two essential proteins, b-ketoacyl-acyl carrier protein (ACP) synthase II (FabF) and III (FabH) whereas platensimycin targets only FabF.

Platencin is soluble in ethanol, methanol, DMF and DMSO. 

    CAS Number

    869898-86-2

    Molecular Formula

    C24H27NO6

    Molecular Weight

    425.2

    Storage Conditions

    -20┬░C

Specifications

    Appearance

    Light tan solid

References

    References

    Isolation and Structure of Platencin: A FabH and FabF Dual Inhibitor with Potent Broad-Spectrum Antibiotic Activity. Jayasuriya H. et al. , Angew. Chem. Int. Ed. 2007, 46, 4684.

    Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties. Wang J. et al. , PNAS 2007, 104, 7612.

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