• Pimecrolimus packaged and labeled in glass vial.

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SKU: P083

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Description
Pimecrolimus is a semi-synthetic, macrocyclic lactone derived from ascomycin by activation of the 32-hydroxy group with a triflate ester, and nucleophilic substitution with chloride under phase transfer conditions to provide the chloro analogue. Pimecrolimus has been targeted for treatment of inflammatory skin disorders. Pimecrolimus is extensively cited in the literature with over 2,000 citations.

Pimecrolimus is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.

    CAS Number

    137071-32-0

    Molecular Formula

    C43H68ClNO11

    Mechanism of Action

    As a tacrolimus analogue pimecrolimus binds to receptor protein FKBP12. The complex then binds to mTOR preventing it from interacting with target proteins.

    Storage Conditions

     -20°C

Specifications

    Appearance

    White solid

References

    References

    Method for preparing pimecrolimus. Gyollai V. & Szabo C. US Patent 7,279,571, 2007.

    Pimecrolimus. Novartis. Schopf R.E. Curr. Opin. Investig. Drugs 2002, 3, 720.

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