• Piericidin A packaged and labeled in glass vial.

click on thumbnail to zoom
SKU: P081

Size  
Quantity:
  Click 'Bulk Order' for 10 or more
Price: make selection(s)
Description
Piericidin A is the major analogue of a family of pyridyl antibiotics isolated from selected Streptomyces species.

Piericidin A is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.

    CAS Number

    2738-64-9

    Molecular Formula

    C25H37NO4

    Molecular Weight

    415.6

    Mechanism of Action

    Piericidin A is a specific, potent inhibitor of NADH-ubiquinone oxidoreductase (Complex I) that binds to ubiquinone binding site(s). Piericidin A inhibits both mitochondrial and bacterial NADH-ubiquinone oxidoreductases, binding close to NUOD-NUOB interface.

    Storage Conditions

    -20┬░C

Specifications

    Appearance

    Pale Yellow Oil

References

    References

    Evidence for a quinone binding site close to the interface between NUOD and NUOB subunits of Complex I. Prieur I. et al. Biochim. Biophys. Acta 2001, 1504, 173.

    '→H+/2e- stoichiometry in NADH-quinone reductase reactions catalyzed by bovine heart submitochondrial particles. Galkin A.S. et al. FEBS Lett. 1999, 451, 157.

    The 49-kDa subunit of NADH-ubiquinone oxidoreductase (Complex I) is involved in the binding of piericidin and rotenone, two quinone-related inhibitors. Darrouzet E. et al. FEBS Lett. 1998, 10, 34.

    Two binding sites of inhibitors in NADH: ubiquinone oxidoreductase (complex I). Relationship of one site with the ubiquinone-binding site of bacterial glucose:ubiquinone oxidoreductase. Friedrich T. et al. Eur J Biochem. 1994, 219, 691.

Other Items In This Category