Piericidin A

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Piericidin A

SKU: P081

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Description

Piericidin A is the major analogue of a family of pyridyl antibiotics isolated from selected Streptomyces species.

Piericidin A is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.

CAS Number

2738-64-9

Molecular Formula

C₂₅H₃₇NO₄

Molecular Weight

415.6

Mechanism of Action

Piericidin A is a specific, potent inhibitor of NADH-ubiquinone oxidoreductase (Complex I) that binds to ubiquinone binding site(s). Piericidin A inhibits both mitochondrial and bacterial NADH-ubiquinone oxidoreductases, binding close to NUOD-NUOB interface.

Storage Conditions

-20°C

Applications

Specifications

Appearance

Pale Yellow Oil

Technical Data

References

Evidence for a quinone binding site close to the interface between NUOD and NUOB subunits of Complex I. Prieur I. et al. Biochim. Biophys. Acta 2001, 1504, 173.

'→H+/2e- stoichiometry in NADH-quinone reductase reactions catalyzed by bovine heart submitochondrial particles. Galkin A.S. et al. FEBS Lett. 1999, 451, 157.

The 49-kDa subunit of NADH-ubiquinone oxidoreductase (Complex I) is involved in the binding of piericidin and rotenone, two quinone-related inhibitors. Darrouzet E. et al. FEBS Lett. 1998, 10, 34.

Two binding sites of inhibitors in NADH: ubiquinone oxidoreductase (complex I). Relationship of one site with the ubiquinone-binding site of bacterial glucose:ubiquinone oxidoreductase. Friedrich T. et al. Eur J Biochem. 1994, 219, 691.