• Paraherquamide A, EvoPure� packaged and labeled in glass vial.

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SKU: P069

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Description
Paraherquamide A was first reported as a mycotoxin related to the indole tremorgenic mycotoxins. Subsequent research identified a potent, non-toxic paralysis of nematodes which led to the metabolite's development as a candidate anthelmintic.

Paraherquamide A is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.

    CAS Number

    77392-58-6

    Molecular Formula

    C28H35N3O5

    Molecular Weight

    493.6

    Mechanism of Action

    Paraherquamide A is a selective, competitive, cholinergic antagonist that distinguishes subtypes of cholinergic receptors.

    Storage Conditions

    -20°C

Specifications

    Appearance

    White Powder

References

    References

    The structure of parherquamide, a toxic metabolite from Penicillium paraherquei. Yamazaki M.E. et al. Tetrahedron Lett. 1982, 22, 135.

    Novel antinematocidal and antiparasitic agents from Penicillium charlesii I. Fermentation, isolation and biological activity. Ondeyka J.G. J. Antibiot. 1990, 43, 1375.

    Paraherquamide and 2-deoxy-paraherquamide distinguish cholinergic receptor subtypes in Ascaris muscle. Robertson A.P. et al. J. Pharmacol. Exp. Ther. 2002, 302, 853.

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