• Ophiobolin C, EvoPure� packaged and labeled in glass vial.

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SKU: O024

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Description
Ophiobolin C is a member of the ophiobolin class of phytotoxic metabolites produced by many species of the genus Bipolaris.

Ophiobolin C is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.

    CAS Number

    19022-51-6

    Molecular Formula

    C25H38O3

    Molecular Weight

    386.6

    Mechanism of Action

    Ophiobolin C inhibits human CCR5 binding to the envelope protein gp120 and CD4 that mediates HIV-1 entry into cells. Blockade of this binding was considered by scientists at Merck as a potential new mode of action for the treatment of HIV-1 infection.

    Storage Conditions

    -20°C

Specifications

    Appearance

    White solid

References

    References

    The structure of zizannin-A and -B, C25-terpenoids isolated from Helminthosporium zizaniae. Nozoe S. et al. , Tetrahedron Lett. 1966, 7, 2211.

    Isolation and structure of antagonists of chemokine receptor (CCR5). Jayasuriya et al. , H. J. Nat. Prod. 2004, 67, 1036.

    The biology of ophiobolins. Au T.K. et al. , Life Sci. 2000, 67, 733. (Review).

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