• Oligomycin C, EvoPure� packaged and labeled in glass vial.

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SKU: O019

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Description
Oligomycin C, a minor component of the oligomycin complex isolated from selected strains of Streptomyces, is an inhibitor of mitochondrial F1F0-ATPase. It makes cells more susceptible to cell death, and also leads to a switch in the death mode from apoptosis to necrosis.

Oligomycin C is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility. 

    CAS Number

    11052-72-5

    Molecular Formula

    C45H74O10

    Molecular Weight

    775.1

    Storage Conditions

    -20°C

Specifications

    Appearance

    White Lyophilisate

References

    References

    Age-dependent cell death and the role of ATP in hydrogen peroxide-induced apoptosis and necrosis. Miyoshi N. et al. Proc. Natl Acad. Sci. USA 2006, 103, 1727.

    Mitochondria in eosinophils: functional role in apoptosis but not respiration. Peachman K.K. et al. Proc. Natl Acad. Sci. USA 2001, 98, 1717.

    The BH3 domain is required for caspase-independent cell death induced by Bax and oligomycin. Fitch M.E. et al. Cell Death Differ. 2000, 7, 338.

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