• Oligomycin A, EvoPure� packaged and labeled in glass vial.

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SKU: O013

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Description
Oligomycin A is the dominant analogue of a class of macrocyclic lactones isolated from selected strains of Streptomyces sp. Oligomycin A exhibits a broad biological profile including antifungal, antitumor and nematocidal activities.

Oligomycin A is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.

    CAS Number

    579-13-5

    Molecular Formula

    C45H74O11

    Molecular Weight

    791.1

    Mechanism of Action

    Oligomycin A is an inhibitor of mitochondrial F1F0-ATPase. It induces apoptosis in a variety of cell types, makes cells more susceptible to cell death, and also leads to a switch in the death mode from apoptosis to necrosis.

    Storage Conditions

    -20°C

Specifications

    Appearance

    White Lyophilisate

References

    References

    Age-dependent cell death and the role of ATP in hydrogen peroxide-induced apoptosis and necrosis. Miyoshi N., et al. , Proc. Natl Acad. Sci. U. S. A., 2006, 103, 1727.

    Mitochondria in eosinophils: functional role in apoptosis but not respiration. Peachman K. K., et al. , Proc. Natl Acad. Sci. U. S. A., 2001, 98, 1717.

    The BH3 domain is required for caspase-independent cell death induced by Bax and oligomycin. Fitch M. E., et al. , Cell Death Differ., 2000, 7, 338.

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