• Ochratoxin A, EvoPure� packaged and labeled in glass vial.

click on thumbnail to zoom
SKU: O014

Size  
Quantity:
  Click 'Bulk Order' for 10 or more
Price: make selection(s)
Description
Ochratoxin A is a chlorinated benzopyran coupled to phenylalanine, produced by several Aspergillus and Penicillium sp. associated with food spoilage. Ochratoxins are widely distributed in the environment and are known to be nephrotoxic, teratogenic and possibly carcinogenic. Ochratoxin A may act by inducing DNA strand breaks, sister chromatid exchanges, DNA adduct formation, or reactive oxygen but the mechanism of action as a toxin is not yet resolved.

Ochratoxin A is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.

    CAS Number

    303-47-9

    Molecular Formula

    C20H18ClNO6

    Molecular Weight

    403.8

    Mechanism of Action

    At the molecular level, ochratoxin A specifically inhibits NK cell activity, increases growth of transplantable tumor cells in mice, increases apoptosis, activates c-Jun N terminal kinase in human kidney epithelial cells, and blocks metaphase/anaphase transition. It also inhibits plasminogen activator inhibitor-2 production by human blood mononuclear cells.

    Storage Conditions

    -20°C

Specifications

    Appearance

    Pale yellow solid

References

    References

    Mycotoxins. Part II. The constitution of ochratoxins A, B, and C, metabolites of Aspergillus ochraceus Wilh. Van der Merwe K. J. et al. , J.C.S. 1965, 7083.

    Ochratoxin A inhibits the production of tissue factor and plasminogen activator inhibitor-2 by human blood mononuclear cells: Another potential mechanism of immune-suppression. Rossiello M.R et al. , Tox. Appl. Pharmacol. 2008, 229, 227.

    Ochratoxin A: Apoptosis and aberrant exit from mitosis due to perturbation of microtubule dynamics? Rached E. et al. , Toxicol. Sci. 2006, 92, 78.

    Selective immunosuppression in mice of natural killer cell activity by ochratoxin A. Luster M.I. et al. , Canc. Res. 1987, 47, 2259.

Other Items In This Category