• Nystatin packaged and labeled.

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SKU: N010

N010  
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Description

Nystatin is a sparingly soluble (0.360 mg/mL) fungicidal and fungistatic polyene antifungal.

    CAS Number

    1400-61-9

    Molecular Formula

    (Nystatin A1) C47H75NO17

    Molecular Weight

    926.09 (Nystatin A1)

    Mechanism of Action

    Nystatin binds ergosterol in the fungal cell membrane forming pores and increasing permeability. The altered permeability is toxic to the fungi leading to growth inhibition or death.

    Storage Conditions

    -20 °C

    Tariff Code

    2941.20.5000

    Spectrum

    Nystatin primarily targets the cell membrane of Candida species especially those which cause vaginal infections.

Specifications

    Form

    Powder

    Appearance

    Yellow Powder

    Source

    Streptomyces noursei and Streptomyces aureus

    pH

    6.0 - 8.0

    Assay

    (Dried Basis): ≥5000 u/mg

    Loss on Drying

    Not more than 5.0%

    Impurities

    Any Impurity: ≤4.0%

References

    References

    Rice L.B. and Ghannoum M.A.. "Antifungal Agents: Mode of Action, Mechanisms of Resistance, and Correlation of These Mechanisms with Bacterial Resistance. Clinical Microbiology Reviews (1999): 501-17.

    Wilson Z.A. and Power, J.B. Elimination of systemic contamination in explant and protoplast cultures of Rubber (Hevea brasiliensis). Plant Ceil Reports 7, 622-62, 1989.

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