SKU: N056

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Description
Nourseothricin is an antibiotic in the Streptothricin class of antibiotics.

    CAS Number

    96736-11-7

    Molecular Formula

    C50H92N20O18 • H2SO4

    Molecular Weight

    1359.46

    Mechanism of Action

    Nourseothricin sulfate inhibits protein synthesis by inducing miscoding.

Applications

    Microbiology Applications

    Nourseothricin sulfate is often used to select for cells with a mutation in the nat1 gene which confers resistance to Nourseothricin. It can be used in yeasts, bacteria, plant cells and filamentous fungi.

References

    References

    Kochupurakkal, B. S., & Iglehart, J. D. (2013). Nourseothricin N-Acetyl Transferase: A positive selection marker for mammalian cells. PLoS ONE, 8(7), e68509. doi:10.1371/journal.pone.0068509

    Krügel, H., Fiedler, G., Haupt, I., Sarfert, E., & Simon, H. (1988). Analysis of the nourseothricin-resistance gene (nat) of Streptomyces noursei. Gene, 62(2), 209–217. doi:10.1016/0378-1119(88)90559-8

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