• Neomycin A sulfate packaged and labeled.

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SKU: N026

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Description

Neomycin A sulfate, EvoPure® also known as neamine is a highly purified neomycin compound found in standard grade neomycin. Neomycin A has been found to have the lowest antibacterial activity; about 10% of the activity of neomycin B. Interestingly, recent research has found neomycin A to inhibit angiogenin translocation in tumor cell nuclei effectively inhibiting tumor growth. Neomycin A (neamine) has a lower toxicity profile than other neomycin components making it a favorable drug for cancer research.

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    CAS Number

    3947-65-7

    Molecular Formula

    C12H26N4O• xH2SO4

    Molecular Weight

    322.358 (Free Base)

    Storage Conditions

    -20°C

    Tariff Code

    2941.90.1010

    Spectrum

    Neomycin is effective against certain Gram negative and Gram positive bacteria; however, neomycin A is most likely less potent than standard grade neomycin or neomycin B.

Applications

    Cancer Applications

    Neomycin A, EvoPure can be used to study its effects on tumor growth and angiogenesis.

Technical Data

HPLC, NMR, FTIR, and MS analysis may be available. For more info, please email [email protected].

References

    References

    Macdonald, R. H., and M. Beck. "Neomycin: A Review with Particular Reference to Dermatological Usage." Department of Dermatology 8 (1982): 249-58. Onlinelibrary.com. Web. 16 July 2013.

    Tsuji, Kiyoshi, and John H. Robertson. "Comparative Study of Responses to Neomycins B and C by Microbiological and Gas-Liquid Chromatographic Assay Methods."Applied Microbiology 18.3 (1969): 396-98. Nih.gov. Web. 23 Oct. 2013.

    Yuan, LingLing, and HongPing Wei. "Rapid Analysis of Native Neomycin Components on a Portable Capillary Electrophoresis System with Potential Gradient Detection."Analytical and Bioanalytical Chemistry 385.8 (2006): 1575-579. Nih.gov. Web. 23 Oct. 2013.

    Robertson, John H. "Antimicrobial Activity of Neomycin C Against Staphylococcus Epidermidis." Applied Microbiology 22.6 (1971): 1164-165. Nih.gov. Web. 23 Oct. 2013.

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