• Natamycin packaged and labeled.

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SKU: N002

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Description

Natamycin is a sparingly soluble (4.1 mg/mL) fungicidal polyene antifungal.

    CAS Number

    7681-93-8

    Molecular Formula

    C33H47NO13

    Molecular Weight

    665.72

    Mechanism of Action

    Natamycin binds membrane bound ergosterol preventing carbohydrate and amino acid transportation by vacuole and membrane mediated fusion. Natamycin does not inhibit synthesis of ergosterol.

    Storage Conditions

    2-8°C

    Tariff Code

    2941.90.1050

    Spectrum

    Natamycin targets fungi responsible for causing ophthalmological complications especially Fusarium species.

Specifications

    Form

    Powder

    Appearance

    White or yellow powder

    Source

    Semi-synthetic

    Melting Point

    280°C

    Assay

    (On Dried Basis): ≥95.0%

    Loss on Drying

    ≤8.0%

References

    References

    Rice L.B. and Ghannoum M.A.. "Antifungal Agents: Mode of Action, Mechanisms of Resistance, and Correlation of These Mechanisms with Bacterial Resistance. Clinical Microbiology Reviews (1999): 501-17.

    Jones, Lynden, Gary Eitzen, and Martin Richard Van Leeuwen. "Natamycin Inhibits Vacuole Fusion at the Priming Phase via a Specific Interaction with Ergosterol." Antimicrobial Agents and Chemotherapy (2009): 2618-615. American Society for Microbiology, 12 Apr. 2010. Web. 22 Aug. 2012.

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