• Nargenicin packaged and labeled in glass vial.

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SKU: N034

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Description
Nargenicin (CP-47,444) is a 10-membered macrocyclic lactone isolated from Nocardia in 1980 as an antibiotic. The macrocyclic lactone is anchored through vicinal carbons to a decalin bearing a pyrrole ester. Nargenicin exhibits potent activity against Gram positive bacteria, in particular MRSA strains. More recently, nargenicin has been shown to enhance retinoate-induced cell differentiation.

Nargenicin is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility. 

    CAS Number

    75923-01-2

    Molecular Formula

    C29H39NO10

    Molecular Weight

    561.6

    Storage Conditions

    -20°C

Specifications

    Appearance

    White solid

References

    References

    Structure of natural antibiotic CP-47,444. Celmer W.D. et al. J. Am. Chem. Soc. 1980, 102, 1203.

    Production, isolation and biological activity of nargenicin from Nocardia sp. CS682. Sohng J.K. et al. Arch Pharm Res 2008, 31, 1339.

    Nargenicin enhances dihydroxyvitamin D-3 and all-trans retinoic acid-induced leukemia cell differentiation via PKC beta I/MAPK pathways. Kim S.H. et al. Biochem. Pharmacol. 2009, 77, 1694.

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