• Nafcillin sodium salt monohydrate

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SKU: N046

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Description
Nafcillin is a beta-lactamase-resistant drug of the penicillin class.

    CAS Number

    7177-50-6

    Molecular Formula

    C21H21N2O5SNa•H2O

    Molecular Weight

    454.47

    Mechanism of Action

    β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases.

    Spectrum

    Nafcillin is targets primarily gram-positive bacteria including Staphylococcus and Streptococcus species.

References

    References

    Guzmán, Flavio, MD. "Beta Lactams Antibiotics (penicillins and Cephalosporins) Mechanism of Action.” Medical Pharmacology. Pharmacology Corner, 29 Nov. 2008. Web. 21 Aug. 2012.

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