• Myriocin packaged and labeled in glass vial.

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SKU: M045

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Description
Myriocin is an α-amino fatty acid derived from several genera of fungi, notably Myriococcum, Melanconis and Isaria.

Myriocin is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.

    CAS Number

    35891-70-4

    Molecular Formula

    C21H39NO6

    Molecular Weight

    401.5

    Mechanism of Action

    Myriocin potently inhibits sphingosine biosynthesis by blocking the first enzyme in the pathway, serine palmitoyltransferase. Myriocin induces apoptosis by depleting cellular sphingolipids, inhibits proliferation of IL-2-dependent mouse cytotoxic cells and is a potent immunosuppressant.

    Storage Conditions

    -20┬░C

Specifications

    Appearance

    Off-white to grey powder

References

    References

    Myriocin, a new antifungal antibiotic from Myriococcum albomyces. Kluepfel D. J. Antibiot. 1972, 25, 109.

    Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin. Miyake Y. et al. , Biochem. Biophys. Res. Commun. 1995, 211, 396.

    Fungal metabolites. Part 12. Potent immunosuppressant, 14-deoxomyriocin, (2S,3R,4R)-(E)-2-amino-3,4-dihydroxy-2-hydroxymethyleicos-6-enoic acid and structure-activity relationships of myriocin derivatives. Fujita T. et al. , J. Biol. Chem. 2005, 280, 10284.

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