• Minocycline packaged and labeled in glass vial.

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SKU: M062

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Description
Minocycline is a semi-synthetic tetracycline prepared by sequential hydrogenolysis, nitration and reductive methylation. Minocycline, together with doxycycline, is regarded as a "third generation" tetracycline largely replacing the natural products and pro-drugs produced in the early 1950s for mainstream antibiotic applications. Like all tetracyclines, minocycline shows broad spectrum antibacterial and antiprotozoan activity. Minocycline has been extensively cited in the literature with over 5,000 references.

Minocycline is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.

    CAS Number

    10118-90-8

    Molecular Formula

    C23H27N3O7

    Molecular Weight

    457.5

    Mechanism of Action

    Minocycline acts by binding to the 30S and 50S ribosomal sub-units, blocking protein synthesis.

    Storage Conditions

    -20┬░C

Specifications

    Appearance

    Yellow to orange solid

References

    References

    The 6-deoxytetracyclines. VII. Alkylated aminotetracyclines possessing unique antibacterial activity. Martel M.J. & Boothe J.H. J. Med. Chem. 1967, 10, 44.

    Synthesis of 7-dimethylamino-6-demethyl-6-deoxytetracycline (minocycline) via 9-nitro-6-demethyl-6-deoxytetracycline. Church R.F.R. et al. J. Org. Chem. 1971, 36, 723.

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