• Methacycline packaged and labeled in glass vial.

click on thumbnail to zoom
SKU: M051

  Click 'Bulk Order' for 10 or more
Price: make selection(s)
Methacycline is a semi-synthetic tetracycline prepared by dehydration of the 6-hydroxy group of oxytetracycline to yield an exocyclic 6-methylene. Like all tetracyclines, methacycline shows broad spectrum antibacterial and antiprotozoan activity. Methacycline has been extensively cited in the literature with over 400 references.

Methacycline is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.

    CAS Number


    Molecular Formula


    Molecular Weight


    Mechanism of Action

    Like all tetracyclines, methacycline acts by binding to the 30S and 50S ribosomal subunits, blocking protein synthesis.

    Storage Conditions




    Yellow to orange solid



    6-Methylenetetracyclines. I A new class of tetracycline antibiotics. Blackwood R.K. et al. J. Am. Chem. Soc. 1961, 83, 2773.

    6-Methylenetetracyclines. III. Preparation and Properties. Blackwood R.K. et al. J. Am. Chem. Soc. 1963, 85, 3943.

    A comparison of the in vitro and in vivo activity of methacycline and other tetracycline compounds. Chang T.W. & Weinstein L. Antibiot. Chemother. 1962, 12, 676.

    Evaluation of methacycline, a new analogue of oxytetracycline. Limson B.M. & Guevara R. Curr. Ther. Res. Clin. Exp. 1963, 5, 249.

Other Items In This Category