• Mebendazole

click on thumbnail to zoom
SKU: M082

Size  
Quantity:
 
Price: make selection(s)
Description
Mebendazole is a broad-spectrum anthelmintic used as a treatment for roundworms. More recently it has been investigated as an anti-cancer agent, showing promise in vitro and in mouse models.

Mebendazole is soluble in formic acid and practically insoluble in water, ethanol, and ether.

    CAS Number

    31431-39-7

    Molecular Formula

    C16H13N3O3

    Molecular Weight

    295.29

    Mechanism of Action

    Like other anitparasitic benzimidazoles, mebendazole inhibits tubulin polymerization. The lack of transportation in the cell causes a build-up of waste and a depletion of energy.

References

    References

    Pantziarka, P., Bouche, G., Meheus, L., Sukhatme, V., & Sukhatme, V. P. (2014). Repurposing Drugs in Oncology (ReDO)—mebendazole as an anti-cancer agent. Ecancermedicalscience, 8, 443. http://doi.org/10.3332/ecancer.2014.443

    Vercruysse, Jozef, DVM, and Edwin Claerebout, DVM. "Mechanisms of Action of Anthelmintics." The Merck Veterinary Manual. Merck & Co., Inc., 2014. Web.

Other Items In This Category