• Mebendazole

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SKU: M082

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Description
Mebendazole is a broad-spectrum anthelmintic used as a treatment for roundworms. More recently it has been investigated as an anti-cancer agent, showing promise in vitro and in mouse models.

Mebendazole is soluble in formic acid and practically insoluble in water, ethanol, and ether.

    CAS Number

    31431-39-7

    Molecular Formula

    C16H13N3O3

    Molecular Weight

    295.29

    Mechanism of Action

    Like other anitparasitic benzimidazoles, mebendazole inhibits tubulin polymerization. The lack of transportation in the cell causes a build-up of waste and a depletion of energy.

Specifications

    Appearance

    White to off-white powder

    Impurity Profile

    Total Impurities:  Not more than 1.0%
    Impurity A:  Not more than 0.25%
    Impurity B:  Not more than 0.25%
    Impurity C:  Not more than 0.25%
    Impurity D:  Not more than 0.25%
    Impurity E:  Not more than 0.25%
    Impurity F:  Not more than 0.25%
    Impurity G:  Not more than 0.50%

    Assay

    (Dried Basis) 99.0% - 101.0%

    Loss on Drying

    Not more than 0.5%

    Sulfated Ash

    Not more than 0.1%

References

    References

    Pantziarka, P., Bouche, G., Meheus, L., Sukhatme, V., & Sukhatme, V. P. (2014). Repurposing Drugs in Oncology (ReDO)—mebendazole as an anti-cancer agent. Ecancermedicalscience, 8, 443. http://doi.org/10.3332/ecancer.2014.443

    Vercruysse, Jozef, DVM, and Edwin Claerebout, DVM. "Mechanisms of Action of Anthelmintics." The Merck Veterinary Manual. Merck & Co., Inc., 2014. Web.

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