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SKU: L041

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Description
Luzopeptin A is a member of the echinomycin (quinomycin A) class of antitumor and antibiotic agents. Luzopeptin A is also a potent inhibitor of HIV-1 reverse transcriptase.

Luzopeptin A is soluble in DMF or DMSO. Moderately soluble in methanol or ethanol. Poor water solubility.

    CAS Number

    75580-37-9

    Molecular Formula

    C64H78N14O24

    Molecular Weight

    1427.4

    Mechanism of Action

    Luzopeptin A acts by forming a stable DNA complex by bis-intercalation.

    Storage Conditions

    -20┬░C

Specifications

    Appearance

    Tan solid

References

    References

    BBM-928, a new antitumor antibiotic complex I. Production, isolation, characterization and antitumor activity. Ohkuma, H. et al. , J. Antibiot. 1980, 33, 1087.

    Screening for inhibitors of avian myeloblastosis virus reverse transcriptase and effect on the replication of AIDS virus. Inouye Y.J. Antibiot. 1987, 40, 100.

    Proton exchange in DNA-luzopeptin and DNA-echinomycin bisintercalation complexes: rates and processes of base-pair opening. Leroy J.L. et al. Biochemistry. 1992, 31, 1407.

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