SKU: L045

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Lignosulfonic acid sodium salt is a lignan-derived macromolecule with antiviral activity, efffective against HIV and HSV in vitro. Lignosulfonic acid is an entry inhibitor, most effective if used upon pre-treatment.

    CAS Number


    Mechanism of Action

    Lignosulfonic acid has multiple cellular targets including viral gp120 as well as host receptor CD4 and co-receptors CCR5/CXCR4.



    Gordts, S. C., Férir, G., D’Huys, T., Petrova, M. I., Lebeer, S., Snoeck, R., . . . Schols, D. (2015). The Low-Cost Compound Lignosulfonic Acid (LA) Exhibits Broad-Spectrum Anti-HIV and Anti-HSV Activity and Has Potential for Microbicidal Applications. PLoS ONE, 10(7). doi:10.1371/journal.pone.0131219

    Qiu, M., Wang, Q., Chu, Y., Yuan, Z., Song, H., Chen, Z., & Wu, Z. (2012). Lignosulfonic Acid Exhibits Broadly Anti-HIV-1 Activity – Potential as a Microbicide Candidate for the Prevention of HIV-1 Sexual Transmission. PLoS ONE, 7(4). doi:10.1371/journal.pone.0035906

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