• Leucinostatin A packaged and labeled in glass vial.

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SKU: L030

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Description
Leucinostatin A is the major component of an atypical nonapeptide complex produced by Paecilomyces lilacinus, first reported in 1973. Leucinostatins display broad bioactivity against Gram positive bacteria, fungi, plants and tumor cell lines. Leucinostatin A is potentiated by inhibitors such as venturicidin and oligomycin. More recently, interest in leucinostatin has focused on understanding its activity as an insulin-like growth factor I regulator, an ionophore, inhibitor of cell surface expression of viral glycoproteins and its anti-trypanosomal activity.

Leucinostatin A is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.

    CAS Number

    76600-38-9

    Molecular Formula

    C62H111N11O13

    Molecular Weight

    1218.6

    Mechanism of Action

    Leucinostatin A inhibits respiration by uncoupling oxidative phosphorylation.

    Storage Conditions

    -20°C

Specifications

    Appearance

    Light tan to tan solid

References

    References

    A new antibiotic, leucinostatin, derived from Penicillium lilacinum. Arai T. et al. J. Antibiot. 1973, 26, 157.

    Isolation of leucinostatin A and one of its constituents, the new amino acid, 4-methyl-6-(2-oxobutyl)-2-piperidinecarboxylic acid, from Paecilomyces lilacinus A-267. Mori Y. et al. J. Antibiot. 1982, 35, 543.

    Dual inhibitory effects of the peptide antibiotics leucinostatins on oxidative phosphorylation in mitochondria. Shima A. et al. Cell Struct. Funct. 1990, 15, 53.

    Leucinostatin A inhibits prostate cancer growth through reduction of insulin-like growth factor-I expression in prostate stromal cells. Kawada M. et al. Int. J. Cancer 2010, 126, 810.

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