• Leucinostatin A packaged and labeled in glass vial.

click on thumbnail to zoom
SKU: L030

  Click 'Bulk Order' for 10 or more
Price: make selection(s)
Leucinostatin A is the major component of an atypical nonapeptide complex produced by Paecilomyces lilacinus, first reported in 1973. Leucinostatins display broad bioactivity against Gram positive bacteria, fungi, plants and tumor cell lines. Leucinostatin A is potentiated by inhibitors such as venturicidin and oligomycin. More recently, interest in leucinostatin has focused on understanding its activity as an insulin-like growth factor I regulator, an ionophore, inhibitor of cell surface expression of viral glycoproteins and its anti-trypanosomal activity.

Leucinostatin A is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.

    CAS Number


    Molecular Formula


    Molecular Weight


    Mechanism of Action

    Leucinostatin A inhibits respiration by uncoupling oxidative phosphorylation.

    Storage Conditions




    Light tan to tan solid



    A new antibiotic, leucinostatin, derived from Penicillium lilacinum. Arai T. et al. J. Antibiot. 1973, 26, 157.

    Isolation of leucinostatin A and one of its constituents, the new amino acid, 4-methyl-6-(2-oxobutyl)-2-piperidinecarboxylic acid, from Paecilomyces lilacinus A-267. Mori Y. et al. J. Antibiot. 1982, 35, 543.

    Dual inhibitory effects of the peptide antibiotics leucinostatins on oxidative phosphorylation in mitochondria. Shima A. et al. Cell Struct. Funct. 1990, 15, 53.

    Leucinostatin A inhibits prostate cancer growth through reduction of insulin-like growth factor-I expression in prostate stromal cells. Kawada M. et al. Int. J. Cancer 2010, 126, 810.

Other Items In This Category