• Lagosin packaged and labeled in glass vial.

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SKU: L024

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Description
Lagosin is a pentaene antifungal produced by Streptomyces, first isolated in 1958 by researchers at MIT in the USA. The discovery was soon followed by several independent isolations as lagosin and cogomyin. Initially these metabolites were thought to be isomeric, but Pandey and colleagues at NCI definitively demonstrated they were identical. Structurally, lagosin is 14-hydroxyfilipin III and the most polar member of the filipin family of fungicides. Lagosin exhibits broad spectrum antifungal and antitumor activity.

Lagosin is soluble in ethanol, methanol, DMF or DMSO.

    CAS Number

    6834-98-6

    Molecular Formula

    C35H58O12

    Molecular Weight

    670.4

    Mechanism of Action

    Lagosin, like filipin, acts via interaction with cell membrane sterols.

    Storage Conditions

    -20°C

Specifications

    Appearance

    Pale yellow to tan solid

References

    References

    Fungichromin: Determination of the structure of the pentaene chromophore. Cope A.C. & Johnson H.E. J. Am. Chem. Soc. 1958, 80, 1504.

    Physicochemical and biological comparison of polyene macrolide antibiotics fungichromin, lagosin and cogomycin. Pandey R.C. et al. J. Antibiot. 1982, 35, 988.

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