• L-Methionine sulfoximine, EvoPure<sup>&reg;</sup>

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SKU: M090

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L-Methionine sulfoximine (MSO) is an inhibitor of the enzyme, glutamine synthetase (GS). L-Methionine sulfoximine, EvoPure® is manufactured in Ghent, Belgium, and has been fully characterized by FTIR, HNMR, HPLC, and mass spectrometry. L-Methionine sulfoximine, EvoPure® is suitable for use as an ancillary material in upstream biomanufacturing applications and processes.

CHO, NS0, and other mammalian cells used in biopharmacutical manufacturing applications are delicate organisms that may respond poorly to lower quality research grade L-Methionine sulfoximine. TOKU-E understands each manufacturing process is different and requires strict and unique quality specifications for maximum yield. The specifications for L-Methionine sulfoximine, EvoPure® can be changed or modified to meet your unique needs and specifications.

For this reason, please contact us for pricing and more information.

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    Mechanism of Action

    L-Methionine sulfoximine is a specific and irreversible inhibitor of glutamine synthetase which catalyzes the formation of glutamine from the condensation of glutamate and ammonia.


    Eukaryotic Cell Culture Applications

    L-Methionine sulfoximine is commonly used in the glutamine synthetase or GS system as a selection agent to select for resistant NS0 or other mammalian cells that have been transfected with a transgene complex containing glutamine synthetase and the gene of interest.






    Wurm, Florian M. "Production of Recombinant Protein Therapeutics in Cultivated Mammalian Cells." Nature.com. Macmillan Publishers, 4 Nov. 2004. Web. 23 Dec. 2016.

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