• Ketoconazole packaged and labeled.

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SKU: K006

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Description

Ketoconazole is an insoluble imidazole antimycotic compound.

This product is considered a dangerous good. Quantities above 1 g may be subject to additional shipping fees. Please contact us for specific questions.

    CAS Number

    65277-42-1

    Molecular Formula

    C26H28Cl2N4O4

    Molecular Weight

    531.43

    Mechanism of Action

    Ketoconazole increases cell permeability by inhibiting enzymes involved in ergosterol synthesis. The increase of permeability has a toxic effect on the fungi and leads to cell death.

    Storage Conditions

    2-8°C

    Tariff Code

    2934.99.3000

    Spectrum

    Ketoconazole is a broad spectrum antifungal agent targeting a wide variety of fungal cell membranes.

Specifications

    Form

    Powder

    Appearance

    White to light yellow powder

    Source

    Synthetic

    Melting Point

    147-151°C

    Assay

    (On Dried Basis): 98.0-102.0%

    Loss on Drying

    ≤0.5%

References

    References

    Rice L.B. and Ghannoum M.A.. "Antifungal Agents: Mode of Action, Mechanisms of Resistance, and Correlation of These Mechanisms with Bacterial Resistance. Clinical Microbiology Reviews (1999): 501-17.

    Van Tyle, J. H. "Ketoconazole. Mechanism of Action, Spectrum of Activity, Pharmacokinetics, Drug Interactions, Adverse Reactions and Therapeutic Use."PubMed (1984): 343-73.

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